Kansas–Nebraska Act
Also called: Bleeding Kansas
By leaving slavery in the Kansas and Nebraska territories to their settlers, the act erased the Missouri Compromise line; bloodshed followed in Kansas and the Republican Party was born to oppose the spread of slavery.

McConnell Map Co. · Public domain · Source
Stephen Douglas wanted to organise territories on the western plains for a transcontinental railroad, and to win Southern votes he wrote in popular sovereignty, leaving slavery to a vote of the settlers. Signed by President Pierce on 30 May 1854, the act in effect repealed the Missouri Compromise (1820), which had barred slavery north of 36°30′.
Pro- and anti-slavery settlers poured into Kansas, set up rival legislatures and attacked each other. When pro-slavery men sacked Lawrence in May 1856, John Brown killed five pro-slavery settlers at Pottawatomie. Dozens died in what became known as “Bleeding Kansas”. Opponents of the act founded the Republican Party in 1854, and the Whig Party collapsed.